E1 - Lessons in Pimple Popping

Aired: April 21, 2025

"Dottie the Body" lost her confidence when a large bump started growing between her thighs; Dr. Lee brings in a new, young doctor to help Tim with his big, bumpy nose; Karime is insecure about her birthmark that looks like a black eye.

E2 - A Juicy Secret

Aired: April 28, 2025

Katrina has oozing, smelly boils that have taken over her life. Kim's head-to-toe tumors interfere with her sleep apnea mask, resulting in constant exhaustion. Dr. Lee and a medical student trainee help Emil and his wife, who are afraid the bump and lesion on his back might be cancerous.

E3 - Superglue to the Rescue

Aired: May 05, 2025

Tierra is a musician with massive bumps on her ears that hold her back from performing. Dr. Zoe assists Dr. Lee helping Ryan, whose numerous head bumps undermine his life journey. Ann keeps a great attitude even as she lives with everyday pain caused by her genetic skin condition.

E4 - Call Me Big Popper

Aired: May 12, 2025

Dr. Lyndsey assists Dr. Lee with Lance's notoriously big bump that halted his rap dreams. Shelby has lost control of her sweet tooth, her health, and the mystery bumps she has developed. Dr. Lee proposes a long-shot cure for Jante, who has been losing pigment in her skin as well as her confidence.

E5 - Senior Cyst-izen

Aired: May 19, 2025

Anthony is trying to move on from his troubled past, but his huge thigh lump is holding him back. Mary has a mysterious 70-year-old bump that amazes Drs. Lee and Tomassian. Sultana has a shocking red rash on her face that affects her social media success.

E6 - Jaw Dropper

Aired: May 26, 2025

Dr. Lyndsey joins Dr. Lee to help David, who is fearful that the lump on his jaw might be cancer. Carla has a large, mysterious bulge on her thigh that concerns Dr. Lee. James has over 70 skin tags that he wants removed so he can get his beach body back.

E7 - Holey Moley

Aired: June 02, 2025

Bill's swinging arm growth prevents him from living his retirement dreams. Regina distracts from the many moles on her face with a vibrant style. Budding med student Gili helps Dr. Lee solve the mystery of Cowboy Carter's extensive rash.

E8 - Tag Team My Bumps

Aired: June 09, 2025

Dr. Lee asks Dr. Zoe to help double-team needle-shy Mary Ann's crusty skin. Isaiah's mom is concerned he is ignoring the large, growing lump over his lower spine. Maressa worries about the dangers of treating the oozing skin covering her ankles and body.

E9 - Triangle of Death

Aired: June 16, 2025

Jason has become a recluse because of a giant growth on the back of his neck.

E10 - Nurse Bumpy Head

Aired: June 23, 2025

Bryan has a genetic condition that may be causing the huge mystery bumps on his head.

E11 - Psoria-Sisters

Aired: June 30, 2025

Dave is a firefighter and avid cyclist whose bump gets in the way of wearing various helmets. Bree empowers others on social media by accepting her own psoriasis, but it has recently become too painful to endure.

E12 - Buffalo Hump Bump

Aired: July 07, 2025

Dee has the voice of an angel, but her huge neck hump has stolen her passion to sing. Young Eli wants to be a chef, but feels ashamed of his cheek bump and worries removing it could paralyze his face.

E13 - My Head Laid An Egg

Aired: July 14, 2025

Stephanie has dreams of being a caterer, but is humiliated by her giant baseball-sized scalp bump. Deb is afraid that the growth on the side of her knee may eventually paralyze her.

E14 - Needle Little Help

Aired: July 21, 2025

Jimmy is a Charleston firefighter whose myriad of torso bumps make it painful to play with his young son.

E15 - Bye Bye Booty Bump

Aired: July 28, 2025

E16 - Hex Marks the Spot

Aired: August 04, 2025

E17 - Third Eye Blinded

Aired: August 04, 2025

E18 - Beach Bump

Aired: August 11, 2025

E19 - My Unlovely Lady Lumps

Aired: August 18, 2025

E20 - Season Finale

Aired: August 25, 2025